BML Joint Publications
A solid beta-sheet structure is formed at the surface of FUS droplets during aging
Leonidas Emmanoulidis, Ettore Bartalucci, Yelena Kan, Mahdiye Ijavi, Maria Escura Pérez, Pavel Afanasyev, Daniel Boehringer, Johannes Zehnder, Sapun H. Parekh, Mischa Bonn,Thomas C. T. Michaels, Thomas Wiegand, Frédéric H.-T. Allain. Nature Chemical Biology (2024)
Specific protein-RNA interactions are mostly preserved in biomolecular condensates
Tebbe de Vries, Mihajlo Novakovic, Yinan Ni, Izabela Smok, Clara Inghelram, Maria Bikaki, Chris P. Sarnowski, Yaning Han, Leonidas Emmanouilidis, Giacomo Padroni, Alexander Leitner, Frédéric H.-T. Allain. Science Advances 10, eadm7435 (2024)
In situ analysis of osmolyte mechanisms of proteome thermal stabilisation
Monika Pepelnjak, Britta Velten, Nicolas Näpflin, Tatjana von Rosen, Umberto Capasso Palmiero, Jeong Hoon Ko, Heather D. Maynard, Paolo Arosio, Eilika Weber-Ban, Natalie de Souza, Wolfgang Huber & Paola Picotti. Nature Chemical Biology (2024)
Glucose stress causes mRNA retention in nuclear Nab2 condensates
Stepanie Heinrich, Maria Hondele, Désirée Marchand, Carina Patrizia Derrer, Mostafa Zedan, Alexandra Oswald, Liliana Malinovska, Federico Uliana, Sarah Khawaja, Roberta Mancini, David Grunwald, Karsten Weis. Cell Reports 43 (1) 113593 (2024).
Integrative solution structure of PTBP1-IRES complex reveals strong compaction and ordering with residual conformational flexibility
Georg Dorn, Christoph Gmeiner, Tebbe de Vries, Emil Dedic, Mihajlo Novakovic, Fred F. Damberger, Christophe Maris, Esteban Finol, Chris P. Sarnowski, Joachim Kohlbrecher, Timothy J. Welsh, Sreenath Bolisetty, Raffaele Mezzenga, Ruedi Aebersold, Alexander Leitner, Maxim Yulikov, Gunnar Jeschke, Frédéric H.-T. Allain. Nature Communications 14, 6429 (2023).
Surface passivation method for the super-repellence of aqueous macromolecular condensates
Andrea Testa, Hendrik T. Spanke, Etienne Jambon-Puillet, Mohammad Yasir, Yanxia Feng, Andreas M. Küffner, Paolo Arosio, Eric R. Dufresne, Robert W. Style, and Aleksander A. Rebane. Langmuir 39, 14626–14637 (2023).
The interface of condensates of the hnRNPA1 low-complexity domain promotes formation of amyloid fibrils
Miriam Linsenmeier, Lenka Faltova, Chiara Morelli, Umberto Capasso Palmiero, Charlotte Seiffert, Andreas M. Küffner, Dorothea Pinotsi, Jiangtao Zhou, Raffaele Mezzenga & Paolo Arosio. Nature Chemistry 15, 1340–1349 (2023).
Global analysis of aging-related protein structural changes uncovers enzyme polymerization-based control of longevity
Jurgita Paukštytė, Rosa María López Cabezas, Yuehan Feng, Kai Tong, Daniela Schnyder, Ellinoora Elomaa, Pavlina Gregorova, Matteo Doudin, Meeri Särkkä, Jesse Sarameri, Alice Lippi, Helena Vihinen, Juhana Juutila, Anni Nieminen, Petri Törönen, Liisa Holm, Eija Jokitalo, Anita Krisko, Juha Huiskonen, L. Peter Sarin, Ville Hietakangas, Paola Picotti, Yves Barral, Juha Saarikangas. Molecular Cell 83 (18) 3360-3376.e11 (2023).
bioRxiv PREPRINT: On the pH-dependence of α-synuclein amyloid polymorphism and the role of secondary nucleation in seeding experiments
Lukas Frey, Dhiman Ghosh, Bilal M. Qureshi, David Rhyner, Ricardo Guerrero-Ferreira, Aditya Pokharna, Witek Kwiatkowski, Tetjana Serdiuk, Paola Picotti, Roland Riek, Jason Greenwald
bioRxiv PREPRINT: Systematic identification of structure-specific protein–protein interactions
Aleš Holfeld, Dina Schuster, Fabian Sesterhenn, Patrick Stalder, Walther Haenseler, Inigo BarrioHernandez, Dhiman Ghosh, Jane Vowles, Sally A. Cowley, Luise Nagel, Basavraj Khanppnavar, Pedro Beltrao, Volodymyr M. Korkhov, Roland Riek, Natalie de Souza, Paola Picotti
Multivalency ensures persistence of a +TIP body at specialized microtubule ends
Sandro M. Meier, Ana-Maria Farcas, Anil Kumar, Mahdiye Ijavi, Robert T. Bill, Jörg Stelling, Eric Dufresne, Michel O. Steinmetz, Yves Barral. Nature Cell Biology (2023) 25, 56-67.
Dynamic arrest and aging of biomolecular condensates are modulated by low-complexity domains, RNA and biochemical activity
Miriam Linsenmeier, Maria Hondele, Fulvio Grigolato, Eleonora Secchi, Karsten Weis, Paolo Arosio. Nature Communications (2022) 13, 3030.
bioRxiv PREPRINT: A conserved mechanism regulates reversible amyloids via pH-sensing regions
Gea Cereghetti, Vera Maria Kissling, Lisa Maria Koch, Alexandra Arm, Pavel Afanasyev, Miriam Linsenmeier, Cédric Eichmann, Jiangtao Zhou, Yiping Cao, Dorota Maria Pfizenmaier, Sonja Kroschwald, Thomas Wiegand, Riccardo Cadalbert, Daniel Böhringer, Raffaele Mezzenga, Paolo Arosio, Roland Riek, Matthias Peter
Non-specific adhesive forces between filaments and membraneless organelles
Thomas J. Böddeker, Kathryn A. Rosowski, Doris Berchtold, Leonidas Emmanouilidis, Yaning Han, Frédéric H. T. Allain, Robert W. Style, Lucas Pelkmans, and Eric R. Dufresne. Nature Physics (2022), 18, 571–578.
Whi3 mnemon association with endoplasmic reticulum membranes confines the memory of deceptive courtship to the yeast mother cell
Yasmin Lau, Henry Patrick Oamen, Marcel Grogg, Iuliia Parfenova, Juha Saarikangas, Robin Hannay, Richard Alan Nichols, Donald Hilvert, Yves Barral, Fabrice Caudron. Current Biology (2022), 32, (5), P963-974.E7
Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly
Gea Cereghetti, Caroline Wilson-Zbinden, Vera M. Kissling, Maren Diether, Alexandra Arm, Haneul Yoo, Ilaria Piazza, Shady Saad, Paola Picotti, D. Allan Drummond, Uwe Sauer, Reinhard Dechant, Matthias Peter. Nature Cell Biology 23, 1085-1094 (2021).
Surface tensiometry of phase separated protein and polymer droplets by the sessile drop method
Mahdiye Ijavi, Robert W. Style, Leonidas Emmanouilidis, Anil Kumar, Sandro M. Meier, Alexandre L. Torzynski, Frédéric H. T. Allain, Yves Barral, Michel O. Steinmetz and Eric R. Dufresne. Soft Matter (2021) 17, 1655-1662