An evolutionarily conserved mechanism controls reversible amyloids of pyruvate kinase via pH-sensing regions
Gea Cereghetti, Vera M. Kissling, Lisa M. Koch, Alexandra Arm, Claudia C. Schmidt, Yannik Thüringer, Nicola Zamboni, Pavel Afanasyev, Miriam Linsenmeier, Cédric Eichmann, Sonja Kroschwald, Jiangtao Zhou, Yiping Cao, Dorota M. Pfizenmaier, Thomas Wiegand, Riccardo Cadalbert, Govind Gupta, Daniel Boehringer, Tuomas P.J. Knowles, Raffaele Mezzenga, Paolo Arosio, Roland Riek, Matthias Peter. Developmental Cell (2024), 59(14) 1876 - 1891.e7
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An evolutionarily conserved mechanism controls reversible amyloids via pH-sensing regions
A recent “Developmental Cell” paper by the Peter group (IBC), in collaboration with the Riek, Arosio, Mezzenga (ETH), and Knowles (Cambridge) groups, reveals an evolutionarily conserved mechanism that regulates amyloid formation and disassembly, profoundly affecting cellular metabolism and growth.
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