2024
Global profiling of protein complex dynamics with an experimental library of protein interaction markers
Christian Dörig, Cathy Marulli, Thomas Peskett, Norbert Volkmar, Lorenzo Pantolini, Gabriel Studer, Camilla Paleari, Fabian Frommelt, Torsten Schwede, Natalie de Souza, Yves Barral, Paola Picotti. Nature Biotechnology (2024).
The molecular dissection of TRIM25’s RNA-binding mechanism provides key insights into its antiviral activity
Lucía Álvarez, Kevin Haubrich, Louisa Iselin, Laurent Gillioz, Vincenzo Ruscica, Karine Lapouge, Sandra Augsten, Ina Huppertz, Nila Roy Choudhury, Bernd Simon, Pawel Masiewicz, Mathilde Lethier, Stephen Cusack, Katrin Rittinger, Frank Gabel, Alexander Leitner, Gracjan Michlewski, Matthias W. Hentze, Frédéric H. T. Allain, Alfredo Castello, Janosch Hennig. Nature Communications (2024) 15:8485.
A structural rationale for reversible vs irreversible amyloid fibril formation from a single protein
Lukas Frey, Jiangtao Zhou, Gea Cereghetti, Marco E. Weber, David Rhyner, Aditya Pokharna, Luca Wenchel, Harindranath Kadavath, Yiping Cao, Beat H. Meier, Matthias Peter, Jason Greenwald, Roland Riek & Raffaele Mezzenga. Nature Communications (2024) 15: 84448.
On the pH-dependence of α-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation
Lukas Frey, Dhiman Ghosh, Bilal M Qureshi, David Rhyner, Ricardo Guerrero-Ferreira, Aditya Pokharna, Witek Kwiatkowski, Tetiana Serdiuk, Paola Picotti, Roland Riek, Jason Greenwald. eLife (2024) 12:RP93562.
Congrats to Paolo, Yves and Karsten for their joint grant!
Paolo, Yves and Karsten together with Michal Wieczorek, Matthias Altmeyer, Cornel Fraefel, Manuel Stucki have secured an SNSF R'EQUIP grant (01.08.2024-31.07.2025) to fund the project "Optical tweezers with fluorescence imaging for investigating the dynamics and mechanics of biological systems" for 463'751 CHF.
An evolutionarily conserved mechanism controls reversible amyloids of pyruvate kinase via pH-sensing regions
Gea Cereghetti, Vera M. Kissling, Lisa M. Koch, Alexandra Arm, Claudia C. Schmidt, Yannik Thüringer, Nicola Zamboni, Pavel Afanasyev, Miriam Linsenmeier, Cédric Eichmann, Sonja Kroschwald, Jiangtao Zhou, Yiping Cao, Dorota M. Pfizenmaier, Thomas Wiegand, Riccardo Cadalbert, Govind Gupta, Daniel Boehringer, Tuomas P.J. Knowles, Raffaele Mezzenga, Paolo Arosio, Roland Riek, Matthias Peter. Developmental Cell (2024), 59(14) 1876 - 1891.e7
Systematic identification of structure-specific protein–protein interactions
Aleš Holfeld, Dina Schuster, Fabian Sesterhenn, Patrick Stalder, Walther Haenseler, Inigo Barrio-Hernandez, Dhiman Ghosh, Jane Vowles, Sally A. Cowley, Luise Nagel, Basavraj Khanppnavar, Tetiana Serdiuk, Pedro Beltrao, Volodymyr M. Korkhov, Sean Munro, Roland Riek, Natalie de Souza, Paola Picotti. Molecular System Biology (2024) 20: 651-675.
A solid beta-sheet structure is formed at the surface of FUS droplets during aging
Leonidas Emmanouilidis, Ettore Bartalucci, Yelena Kan, Mahdiye Ijavi, Maria Escura Pérez, Pavel Afanasyev, Daniel Boehringer, Johannes Zehnder, Sapun H. Parekh, Mischa Bonn,Thomas C. T. Michaels, Thomas Wiegand, Frédéric H.-T. Allain. Nature Chemical Biology (2024) 20, 1044–1052.
Specific protein-RNA interactions are mostly preserved in biomolecular condensates
Tebbe de Vries, Mihajlo Novakovic, Yinan Ni, Izabela Smok, Clara Inghelram, Maria Bikaki, Chris P. Sarnowski, Yaning Han, Leonidas Emmanouilidis, Giacomo Padroni, Alexander Leitner, Frédéric H.-T. Allain. Science Advances 10, eadm7435 (2024)
In situ analysis of osmolyte mechanisms of proteome thermal stabilisation
Monika Pepelnjak, Britta Velten, Nicolas Näpflin, Tatjana von Rosen, Umberto Capasso Palmiero, Jeong Hoon Ko, Heather D. Maynard, Paolo Arosio, Eilika Weber-Ban, Natalie de Souza, Wolfgang Huber & Paola Picotti. Nature Chemical Biology (2024) 20, 1053-1065
Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics
Basavraj Khanppnavar, Dina Schuster, Pia Lavriha, Federico Uliana, Merve Özel, Ved Mehta, Alexander Leitner, Paola Picotti, Volodymyr M Korkhov. EMBO Reports (2024) 25, 1513
The 100-protein NMR spectra dataset: A resource for biomolecular NMR data analysis
Piotr Klukowski, Fred F. Damberger, Frédéric H.-T. Allain, Hideo Iwai, Harindranath Kadavath, Theresa A. Ramelot, Gaetano T. Montelione, Roland Riek, Peter Güntert. Scientific Data (2024) 11: 30.
Glucose stress causes mRNA retention in nuclear Nab2 condensates
Stepanie Heinrich, Maria Hondele, Désirée Marchand, Carina Patrizia Derrer, Mostafa Zedan, Alexandra Oswald, Liliana Malinovska, Federico Uliana, Sarah Khawaja, Roberta Mancini, David Grunwald, Karsten Weis. Cell Reports 43 (1) 113593 (2024).